在有机化合物中毒后,精密切割的肺部切片中ACHE的重新激活
Fee Gölitz1, Julia Herbert2, Franz Worek3
1Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany; Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University, Munich, Germany.
Toxicology letters
|December 31, 2023
概括
精密切割的肺切片有效地模拟了有机神经毒剂的暴露,显示了对乙胆酶活性的多种活性剂疗效. 这项研究有助于开发神经毒剂中毒的改善治疗方法.
科学领域:
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
- 在体外模型模型.
背景情况:
- 有机神经毒剂 (OPNA) 抑制乙胆酶 (AChE),导致中毒.
- 目前对OP中毒的治疗方法在有效性上有局限性.
- 新的治疗策略需要可靠的模型来评估.
研究的目的:
- 为了研究OPNA暴露后精密切割肺切片 (PCLS) 中的ACHE活性和气道变化.
- 评估不同活性剂在恢复 AChE 活性的有效性.
- 为了将分子ACHE活动与功能性呼吸道反应相关联.
主要方法:
- 完整的PCLS暴露于沙林 (GB),环沙林 (GF) 和VX.
- 测量了ACHE活动和气道面积 (AA) 的变化.
- 治疗PCLS患者的活性剂包括HI-6,obidoxime (OBI) 和non-oxime (NOX-6).
主要成果:
- 在PCLS中,OPNA暴露显著降低了ACHE活性.
- 再激活疗效因OPNA和活性剂而异:GB抑制的ACHE显示出最好的恢复,其次是VX和GF.
- 结果与观察到的呼吸道区域变化相关.
结论:
- 对于研究OPNA毒性和评估治疗性活性剂来说,PCLS是一个有价值的模型.
- 再激活器的选择对ACHE恢复有重大影响.
- 这些发现支持开发针对OPNA暴露的改进治疗方法.
关键词:
3 R R 3 R 3 R R 3 R R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 3 R 4 R 5 R 时间表情是什么意思的肺部毒性 肺部毒性 肺部毒性神经毒剂是一种神经毒剂.氧化物是氧化物中的一种.在PCLS中使用PCLS.相关概念视频
Depolarizing Blockers: Pharmocokinetics
327
Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
327
Depolarizing Blockers: Mechanism of Action
1.6K
Depolarizing blockers act on skeletal muscle fibers' membranes and induce their depolarization. Most depolarizing blockers have two quaternary N+ atoms that bind the nicotinic acetylcholine receptors and cause neuromuscular blockade within minutes.
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because...
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because...
1.6K


