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前带状皮质及其与背部周水道灰色的接口调节氧化介导的恐慌性行为和防御性反恐感受

Luiz Luciano Falconi-Sobrinho¹, Tayllon Dos Anjos-Garcia², Macário Arosti Rebelo³

¹Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (USP), Av. Bandeirantes 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil; Behavioural Neurosciences Institute (INeC), Psychobiology Division, Av. Bandeirantes, 3900, Ribeirão Preto, 14049-900, São Paulo, Brazil.

Neuropharmacology

|December 31, 2023

概括

前带状皮质 (ACC) 24b区域通过与背部周水管灰质 (dPAG) 的连接调节先天的恐惧反应. 这一途径涉及基神经元,影响诸如逃跑和结之类的防御行为.

科学领域:

神经科学是一个神经科学.
行为神经科学行为神经科学
神经解剖学是一个神经解剖学.

背景情况:

确定前带带皮层 (ACC) Cg1 (24b) 区域在调节恐惧和疼痛方面的作用.
它通过与背部周水管灰质 (dPAG) 的连接来调节防御反应仍然没有特征.
该dPAG是一个关键的中脑结构在先天的恐惧诱导防御.

研究的目的:

调查ACC 24b区域活动与dPAG功能在先天性恐惧反应中的相关性.
描述连接24b区域和dPAG的神经通路的特征.
在这个电路中检查dPAG中基神经元的作用.

主要方法:

在被蛇威胁的小鼠的ACC 24b区域内注射NMDA或利多卡因.
评估行为反应 (逃跑,结,风险评估).
在dPAG中测量Fos蛋白表达和基活性.
神经通道追踪以确定24b区域-dPAG连接.
在dPAG中药理上抑制神经元氧化合成酶 (nNOS).

主要成果:

激活ACC 24b区域的NMDA受体增强了dPAG中的逃逸,结,Fos表达和酸盐水平.
在ACC 24b区域的利多卡因失活减少了逃逸,风险评估,Fos表达和基活性.
抑制dPAG nNOS可以逆转NMDA诱导的恐慌效应和增加恶性感知.
管道追踪证实了从24b区域到dPAG的直接投射.

结论:

ACC/24b区域通过dPAG调节天生的防御行为.
在dPAG中的基神经元是这种恐惧调节电路的关键组成部分.
这项研究阐明了一种新的神经通路,它是内在恐惧反应的基础.

关键词:

前带带皮层前带带皮层科罗塔卢斯 (Crotalus durissus terrificus) 是一个可怕的植物.防御性的行为.恐惧诱导的止痛药是恐惧引起的止痛药.它们是NMDA受体.氧化氧化是什么?周边水管灰色物质的灰色物质

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