短效尼古丁替代疗法产品的类型切换及其对治疗的影响
Scott Veldhuizen1, Laurie Zawertailo2, Peter Selby3
1Nicotine Dependence Services, Centre for Addiction and Mental Health, 1025 Queen St W - 3342, Toronto M6J 1H1, ON, Canada; Department of Family and Community Medicine, University of Toronto, Canada.
许多人转换尼古丁替代疗法 (NRT) 产品. 了解这些尼古丁口香糖,药片,吸入器或口腔喷雾器的切换速率可以为戒烟策略提供信息.
科学领域:
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
- 行为科学 行为科学
背景情况:
- 患者的满意度影响了治疗的坚持和转换行为.
- 短效尼古丁替代疗法 (NRT) 产品在输送,发病和副作用方面有所不同.
- 了解NRT产品切换对于优化戒烟干预措施至关重要.
研究的目的:
- 分析不同短效NRT产品之间的切换速率.
- 为了确定与切换NRT产品相关的因素.
- 为改善戒烟成果的策略提供信息.
主要方法:
- 对46,882名参与安大略省患者吸烟治疗计划的观察数据的二次分析.
- 离散时间生存分析以建模NRT产品切换的时间.
- 包括时间对产品和产品对先前戒烟尝试的相互作用,调整以社会人口统计学和烟草使用变量.
主要成果:
- 总体而言,37.9%的参与者在第一次随访时更换了NRT产品.
- 调整后的切换概率:口香糖为21.1%,药片为23.8%,吸入器为26.0%,口服喷雾为28.8%.
- 在没有先前戒烟尝试的个人,女性和同时使用尼古丁贴片的人群中观察到更高的切换率.
结论:
- 短效NRT产品之间经常发生切换,可能是由于不良影响,不便或被认为无效.
- 多种NRT产品的可用性可以提高治疗坚持性,并改善戒烟成功.
- 对切换和优化NRT组合的原因进行进一步的研究是有必要的.
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