怀孕期间糖尿病后患乳腺癌的风险:基于人口的队列研究
Gurjot Gill1, Vasily Giannakeas2, Stephanie Read3
1Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada.
Canadian journal of diabetes
|December 31, 2023
概括
怀孕期间的糖尿病不会增加短期的乳腺癌风险. 妊娠期糖尿病 (GDM) 的发病率较低,而其他癌症可能在怀孕后更常见.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 糖尿病是众所周知的各种癌症的风险因素.
- 关于怀孕期间糖尿病与随后的乳腺癌风险之间的关联现有证据是不一致的.
- 这项研究调查了糖尿病和没有糖尿病的妇女怀孕后的癌症发病率.
研究的目的:
- 为了比较患有孕期糖尿病 (GDM) 和孕期糖尿病 (孕期DM) 的女性与没有糖尿病的女性的乳腺癌和其他特定部位癌症的发病率.
- 评估与怀孕期间糖尿病状况相关的分娩后后续癌症的短期风险.
主要方法:
- 在加拿大安大略省利用基于人口的医疗保健数据库进行了回顾性队列研究.
- 根据年龄,平价和分娩年份,将GDM和孕期DM与没有糖尿病 (非DM) 的分娩的倾向性得分匹配 (1:2比).
- 产后的随访,以确定乳腺癌 (原发性) 和其他癌症 (二次性) 的发病率,使用Cox比例危险回归.
主要成果:
- 在8年的中位数中,孕期糖尿病的分娩与乳腺癌发病率显著降低相关 (HR 0.90,95% CI 0.82-0.98).
- 与非妊娠糖尿病分娩相比,孕期糖尿病患者的乳腺癌发病率相似 (HR 0.92,95% CI 0.80-1.07).
- 孕期糖尿病与胰腺癌和肝细胞癌的风险增加有关;孕期糖尿病与甲状腺癌,肝细胞癌和子宫内膜癌的风险增加有关.
结论:
- 怀孕期间的糖尿病与随后患乳腺癌的短期风险增加无关.
- 糖尿病导致的妊娠并发症可能与某些其他癌症的发病率增加有关.
- 需要进一步的研究来了解长期影响和特定的癌症风险.
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