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IL-10抑制抗瘤免疫力,并通过PD-L1诱导促进肝转移

Ahmad Mustafa Shiri1, Tao Zhang1, Tanja Bedke1

  • 1Section of Molecular Immunology and Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Journal of hepatology
|December 31, 2023
PubMed
概括

调节性T细胞 (Tregs) 通过产生IL-10驱动肝转移,该IL-10可在单细胞上调节PD-L1,从而阻碍抗瘤免疫力. 向IL-10可能会改善结直肠癌肝脏转移的免疫疗法.

关键词:
在 IL-10 中,IL-10 是 IL-10 的代表.在PD-L1中.免疫细胞 免疫细胞免疫疗法 免疫疗法肝脏转移的发生.

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