在SARS-CoV-2感染和SARS-CoV-2疫苗接种后的自身免疫反应
Altijana Hromić-Jahjefendić1, Kenneth Lundstrom2, Muhamed Adilović1
1Department of Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, International University of Sarajevo, Hrasnicka cesta 15, 71000 Sarajevo, Bosnia and Herzegovina.
Autoimmunity reviews
|December 31, 2023
概括
COVID-19感染和接种疫苗可以引发自身免疫反应,在患者身上检测到各种自身抗体. 了解这些复杂的免疫反应对于管理COVID-19后的自身免疫疾病至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 这是一种自身免疫力.
背景情况:
- COVID-19 与自身免疫反应的高患病率有关.
- 在COVID-19患者中经常观察到抗核抗体 (ANA) 和抗Ro/SSA等自身抗体.
- SARS-CoV-2 和人类蛋白质之间的结构相似性表明了自身抗原发育的机制.
研究的目的:
- 描述自身免疫,COVID-19和COVID-19疫苗接种之间的复杂关系.
- 为了展示COVID-19相关自身免疫的起源的可能途径.
- 提供关于COVID-19疫苗当前状态的最新摘要.
主要方法:
- 审查关于自身免疫和COVID-19的现有文献.
- 在COVID-19患者中分析自身抗体的流行率.
- 讨论推动COVID-19自身免疫力的潜在机制.
主要成果:
- 在COVID-19患者中一致检测到ANA,抗Ro/SSA,类风湿因子,狼抗凝剂和抗干扰素 (IFN) -I抗体.
- 识别具有与SARS-CoV-2酸具有结构相似性的人类蛋白质作为潜在的自身抗原.
- 包括旁观者激活,病毒持久性和中性粒细胞外细胞陷在COVID-19自身免疫中的途径的阐明.
结论:
- COVID-19显著影响免疫系统,导致广泛的自身免疫和炎症性疾病.
- 了解COVID-19引起的自身免疫机制对于临床管理至关重要.
- 需要进一步的研究才能充分阐明COVID-19对自身免疫性疾病的长期后果.
相关概念视频
Vaccinations
44.5K
Overview
44.5K
Immune Response Against Viral Pathogens
789
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
789
Immunological Memory
622
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
622
Cross-reactivity
31.1K
Overview
31.1K
Autoimmune Disorders
443
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
443
Cell-mediated Immune Responses
68.3K
Overview
68.3K


