十二指肠和胰腺组织微生物组的个人资料,PPI使用者和非使用者
Takeichi Yoshida1, Mohamad Dbouk1, Katsuya Hirose1
1Departments of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
概括
质子抑制剂 (PPI) 的使用改变了十二指肠微生物组,增加了链球菌. 虽然PPI没有显著改变胰腺微生物组,但在胰腺头部和身体/尾部组织之间观察到差异.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 在瘤学瘤学.
背景情况:
- 影响胰腺微生物群的因素尚不清楚.
- 质子抑制剂 (PPI) 的使用显著改变了肠道微生物群,可能增加胰腺癌的风险.
- 了解PPI对胰腺和十二指肠组织的影响至关重要.
研究的目的:
- 调查PPI使用与胰腺和十二指肠组织微生物组之间的关联.
- 为了比较不同胰腺区域 (头与身体/尾部) 的微生物组概况.
- 分析主要胰腺管扩张对组织微生物组相似性的影响.
主要方法:
- 16S rRNA测序被用于对103名患者的胰腺和十二指肠组织的微生物组进行分析.
- 包括因非恶性病症而接受手术的患者,其中34人是PPI患者.
- 统计分析考虑了年龄,吸烟,BMI和主要胰腺管扩张.
主要成果:
- 与身体/尾巴组织相比,胰腺头组织显示出更高的α多样性和菌菌和链球菌的丰富性.
- 与非使用者相比,PPI使用者的十二指肠组织表现出增加的Firmicutes和Streptococcus丰富度.
- 抗胰岛素使用与十二指肠α多样性和一些胰腺组织β多样性差异有关,但与胰腺α多样性无关.
结论:
- 在胰腺头部和身体/尾部组织之间存在不同的微生物组配置.
- 使用PPI与十二指肠微生物组的显著变化有关.
- 虽然对胰腺微生物组的直接影响较少,但PPI可能间接影响胰腺组织的微生物组成.
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