在脂蛋白中的甘油三度的影响 (a) 作为失脂血症的函数
Victoria Marco-Benedí1, Ana Cenarro2, Martín Laclaustra1
1Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), CIBERCV, Zaragoza, España; Universidad de Zaragoza, Zaragoza, España.
概括
这项研究显示,在没有糖尿病,肥胖或家族性高胆固醇血症的个体中,脂蛋白 (Lp) 和甘油三 (TG) 之间存在逆关系,特别是当TG水平超过300 mg/dL时.
科学领域:
- 心血管研究研究心血管研究
- 脂质代谢 脂质代谢是什么
- 动脉样硬化是一种动脉样硬化.
背景情况:
- 已经观察到脂蛋白 (Lp) 和甘油三 (TG) 之间的反向关系.
- 这种关联的潜在机制,特别是关于VLDL粒子大小和apoE基因型,仍然不清楚.
- 以前的发现表明VLDL颗粒较大,apoE2/E2基因型与较低的Lp (a) 水平相关.
研究的目的:
- 调查西班牙动脉样硬化学会注册表中患者Lp(a) 和Tg度之间的关联.
- 为了比较不同类型的脂质失调症之间的Lp(a) -TG关系.
- 阐明观察到的反相关性背后的潜在机制.
主要方法:
- 分析了来自西班牙动脉样硬化学会注册表的5275名成年受试者,并提供了Lp (a) 和脂质资料数据.
- 纳入标准指的是目前没有任何降脂治疗,以及在2023年3月31日之前收集的数据.
- 根据甘油三水平,糖尿病,肥胖和家族性高胆固醇血症对受试者的分层.
主要成果:
- 在没有糖尿病或肥胖的人群中,当TG水平超过300 mg/dL (p < 0.001) 时,观察到Lp (a) 和TG之间的反向关联.
- 与TG<300 mg/dL (平均60.1 nmol/L) 相比,TG>1000 mg/dL的受试者表现出最低的Lp (a) 水平 (中位数为17.9 nmol/L),而TG<300 mg/dL的受试者则表现出最低的Lp (a) 水平 (中位数为17.9 nmol/L).
- 在患有糖尿病,肥胖或家族性高胆固醇血症的受试者中没有发现显著的关联,这表明这些条件改变了Lp(a) -TG关系.
结论:
- 这项研究证实,在TG > 300 mg/dL的个体中,Lp(a) -TG关系是逆的,特别是在没有糖尿病,肥胖或家族性高胆固醇血症的人中.
- 这些发现表明,由肝脏VLDL过量产生的高甘油三血症可能涉及减少Lp (a) 形成.
- 相反,TG丰富的脂蛋白的外周代谢受损可能不会以同样的方式影响Lp (a) 水平.
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