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奶酪消费对动脉样硬化,动脉样硬化心血管疾病及其并发症的影响:一项两样本的门德尔随机化研究
Yingying Xie1, Hao Chen2, Jin Xu3
1Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, PR China; Department of Cardiology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|December 31, 2023
概括
这项研究发现,食用奶酪与降低患动脉样硬化 (AS) 和动脉样硬化心血管疾病 (ASCVD) 的风险有因果关系. 这些发现支持将奶酪作为心脏健康饮食的一部分.
科学领域:
- 心血管科学 心血管科学
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究表明,奶酪消费与动脉样硬化 (AS) 和动脉样硬化性心血管疾病 (ASCVD) 之间存在反向关系.
- 长期观察研究中的潜在混因素可能会掩盖奶酪摄入量与AS/ASCVD之间的真正关系.
- 需要因果推断来澄清饮食奶酪摄入量与心血管健康结果之间的关联.
研究的目的:
- 调查奶酪消费与发展动脉样硬化 (AS) 和动脉样硬化性心血管疾病 (ASCVD) 以及其并发症的风险之间的因果关系.
- 利用双样本的门德尔随机化 (MR) 方法来评估遗传预测奶酪摄入量对各种心血管结果的潜在因果影响.
主要方法:
- 使用公开可用的全基因组关联研究 (GWAS) 数据进行了两样本的门德尔随机化 (MR) 分析.
- 使用随机效应的反变量加权 (IVW) 方法用于估计因果关系.
- 为了确保发现的稳定性,进行了包括科克兰的Q统计,漏斗图和MR-Egger拦截测试在内的灵敏度分析.
主要成果:
- 基因预测较高的奶酪摄入量与冠状动脉AS (OR=0.72),外周血管AS (OR=0.56) 和其他血管AS (OR=0.66) 的风险显著降低有关.
- 对冠状动脉疾病 (OR=0.64),胸痛 (OR=0.70),心肌梗塞 (OR=0.63),心力衰竭 (OR=0.62),全缺血性中风 (OR=0.76) 和外周动脉疾病 (OR=0.64) 观察到显著的逆相关性.
- 对于脑血管AS,心律失常,心脏死亡或缺血性中风的特定亚型,没有发现显著的关联.
结论:
- 这项研究证实了奶酪摄入量与多种形式的血管动脉样硬化和动脉样硬化心血管疾病之间的因果逆关系.
- 这些发现表明,奶酪消费可能在心血管疾病的发展中起着保护作用.
- 这些结果为将奶酪纳入管理和预防动脉样硬化心血管疾病的饮食策略提供了更强大的理论基础.
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