一项纵向研究,研究肥胖对正常怀孕中循环氨酸 - 血管新生系统的影响
Stella Bernardi1, Federica Tonon2, Moira Barbieri2
1Department of Medical Surgical and Health Sciences, University of Trieste, 34149, Trieste, Italy; Unit of Endocrinology, ASUGI, Cattinara Teaching Hospital, 34149, Trieste, Italy.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|December 31, 2023
概括
肥胖的孕妇表现出增加的 ангиотензинII (AngII) 和 AngII/ ангиотензин-1-7 (Ang1-7) 水平,与降低胎盘血液供应有关. 这表明,胺-血管素系统 (RAS) 失调在怀孕并发症之前.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 心血管生理学心血管生理学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 肥胖是生育年龄妇女的一个普遍问题,影响着孕产妇和胎儿的健康.
- 怀孕期间肥胖对心血管的影响尚未完全理解.
- 已知炎症和代谢变化,但氨酸-血管新生素系统的作用尚不清楚.
研究的目的:
- 为了评估怀孕期间肥胖女性与正常体重女性的氨酸- ангиотензин系统 (RAS) 的变化.
- 为了研究母亲的血液动力学和肥胖妊娠中的RAS变化之间的关联.
- 了解肥胖怀孕中心血管表型的早期病变发生.
主要方法:
- 一项比较性研究,包括38名正常体重和19名肥胖的孕妇.
- 在多个妊娠点 (12,20,30,36周) 进行临床,血液动力学和超声波参数的连续评估.
- 通过ELISA量化RAS组件 (血管新生素,Renin,AngII,Ang1-7,ACE,ACE2) 和血管新生因子 (sFlt-1,PlgF).
主要成果:
- 与对照组相比,正常压力肥胖妇女的胎盘血液供应减少 (UV-Q,UV-Q/EFW).
- 在肥胖女性中观察到显著增加的 ангиотензинII (AngII) 水平和更高的AngII/ ангиотензин- ((1-7) (Ang1-7) 比率.
- 这些RAS变化与胎盘血液供应相反相关.
结论:
- 在整个妊娠期间,正常的肥胖孕妇表现出AngII和AngII/Ang1-7的逐渐增加.
- RAS失调似乎是肥胖怀孕的早期事件,可能是高血压疾病的前身.
- 研究结果表明,RAS失衡是肥胖妇女不良妊娠结果的先决条件,而不是后果.
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