相对脂肪量与全因和心血管死亡率之间的关系中的性别差异:基于人口的前性队列研究
Jing Wang1, Jingyuan Guan1, Liyan Huang1
1State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|December 31, 2023
概括
新型的相对脂肪质量 (RFM) 方程预测心脏代谢风险和死亡率. 在RFM中性别特异性差异.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 人类测量学 人类测量学.
背景情况:
- 相对脂肪质量 (RFM) 是一种新的性别特定的人类测量方程,估计全身脂肪百分比.
- 评估肥胖和相关健康风险的现有方法存在局限性.
研究的目的:
- 调查RFM在心脏代谢异常,心血管疾病 (CVD) 和死亡率中的预测作用.
- 探索RFM预测能力中的潜在性别差异.
主要方法:
- 对26,754名成年人的数据进行分析 (NHANES 1999-2010),随访时间中位数为13.8年.
- 在RFM和身体成分之间的相关性分析 (双能X射线吸收计).
- 使用了加权多变量通用线性模型和考克斯比例危险模型.
主要成果:
- RFM与全身和干部脂肪百分比有很强的相关性.
- 较高的RFM与男性的葡萄糖,脂质,高血压和冠状动脉心脏病受损有关.
- 较高的RFM与女性的C-反应蛋白有关;在男性中观察到U形死亡风险.
结论:
- RFM作为一般和中心肥胖的性别特定估计器.
- 对于RFM对不良结果的预测能力的性别特异性差异可能源于身体组成和脂肪分布的变化.
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