脑子在体外平台:与活神经元交互的多功能,可扩展,坚固和开放的解决方案
Xiaotian Zhang1, Zhi Dou2, Seung Hyun Kim2
1Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|December 31, 2023
概括
研究人员开发了一种负担得起的,开源的"脑在体外"神经接口系统. 这种多功能平台可实现可扩展的记录和刺激,用于各种in vitro神经应用.
科学领域:
- 神经科学是一个神经科学.
- 生物工程是生物工程.
- 计算神经科学是一种神经科学.
背景情况:
- 试管神经系统为先进的计算提供了尚未开发的潜力.
- 需要多功能,可扩展的接口来实现多模式神经交互.
研究的目的:
- 为体外神经系统提供准确,模块化,可定制和便携式的记录/刺激解决方案.
- 实现从神经基板到数据分析和云存储的完整信号链.
主要方法:
- 一个可重新配置的平台,支持多个行业标准.
- 用于定制微电极阵列 (MEA) 制造的无面膜光刻法.
- 电/光刺激和流体接口的整合.
主要成果:
- 在多种神经文化中 (初级神经元,干细胞衍生神经元,脑切片,3D组织模仿) 证明了实用性和稳健性.
- 启用并发成像和长期电生理学记录.
- 与现有解决方案相比,实现了十倍以上的成本降低.
结论:
- 这是一个很棒的节目,这是一个很棒的节目.
- 头脑在体外试验中的体外试验.
- 该系统为神经电生理学提供了一个端到端的解决方案.
- 它的开源和负担得起的性质有利于广泛传播和采用.
- 该技术满足了传统和非传统神经科学研究中不断扩大的需求.
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