辐射周毛细血管密度作为眼睛高血压的眼睛中青光眼的预测因素. 一个观察性,比较性,单一中心研究
Elpida Kollia1, Evita-Evangelia Christou2, Eleni Patsea3
1Division of Ophthalmology, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Attica, Greece.
F1000Research
|January 1, 2024
概括
与健康对照人群相比,眼睛高血压 (OH) 眼睛显示辐射周毛细血管密度降低. 较低的周皮囊微循环变化可以预测青光眼的进展.
科学领域:
- 眼科医生 眼科 眼科
- 微循环研究 微循环研究
- 青光眼的诊断 青光眼的诊断
背景情况:
- 眼睛高血压 (OH) 涉及高眼内压 (IOP) 没有视神经损伤.
- 高血压是发展青光眼的主要危险因素,是不可逆转失明的主要原因.
- 在OH的微循环变化可能预测青光眼的进展.
研究的目的:
- 为了研究眼睛高血压患者的辐射周毛细血管的微循环变化.
- 使用光学连贯断层扫描血管学 (OCT-A) 进行详细的微循环分析.
- 鉴定与OH相关的微循环变化导致青光眼发育的潜在生物标志物.
主要方法:
- 对192只眼睛的观察性比较研究 (OH与健康对照).
- OCT-A用于评估周囊细胞微循环特征.
- 在光盘区域测量了辐射周毛细血管密度;分析了年龄,治疗,性别和视网膜纤维层厚度.
主要成果:
- 与对照组相比,OH眼睛的总辐射周毛细血管密度明显较低.
- 在OH患者中,较低的周周毛细毛细血管密度显著下降.
- 较高的外皮囊和内部光盘毛细血管密度在两组之间没有显著差异.
结论:
- 患有眼睛高血压的眼睛表现出辐射周毛细血管密度降低.
- 微循环的改变,特别是在较低的周囊区域,可以作为OH进展到青光眼的生物标志物.
更多相关视频
相关概念视频
01:25Glaucoma: Overview
574
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
574
01:27Open Angle Glaucoma: Treatment
453
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
453