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双边点状角膜炎和风角膜病变在阿普雷米拉斯特治疗后发生
Logan Wolfel1, Jimena Franco1, Thomas Bradford Gillette1
1Department of Ophthalmology and Visual Sciences, University of New Mexico School of Medicine, Albuquerque, NM, USA.
American journal of ophthalmology case reports
|January 1, 2024
概括
阿普雷米拉斯特治疗可能会导致双边点状角膜炎,这种情况类似于风角膜病变. 本案例报告强调了阿普雷米拉斯的潜在眼部副作用,强调了临床意识的必要性.
科学领域:
- 眼科医生 眼科 眼科
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 牛皮是一种慢性炎症性皮肤疾病.
- 阿普雷米拉斯特是一种口服化酶4抑制剂,用于治疗牛皮.
- 阿普雷米拉斯的眼部副作用并不常见,但需要进行调查.
研究的目的:
- 报告单一的双边点状角膜炎病例.
- 描述在阿普雷米拉斯治疗期间与风角质病变相一致的表现.
- 提高人们对阿普雷米拉斯的潜在眼部不良影响的认识.
主要方法:
- 一个49岁的女性患者的病例报告.
- 详细的眼科检查和病史.
- 在Apremilast治疗和中止之前,期间和之后观察临床表现.
主要成果:
- 患者出现了严重的,疼痛的,双边点状角膜炎,形状类似旋转.
- 停用阿普雷米拉斯和开始局部类固醇后,症状显著改善.
- 在十周内观察到完全的角膜愈合和视力恢复.
结论:
- 这是第一个报告的角膜上皮质角膜炎病例,类似于风角膜病变,与apremilast相关.
- 艾普雷米拉斯特诱导的角质炎应该被视为潜在的副作用.
- 眼科医生和皮肤科医生应该意识到这种可能的不良反应.
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