索利达哥微光的心脏保护作用DC. 在尼古丁治疗的高血压大鼠中
Katiana Simões Lopes1, Aline Aparecida Macedo Marques1, Karyne Garcia Tafarelo Moreno1
1Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS, Brazil.
Evidence-based complementary and alternative medicine : eCAM
|January 1, 2024
概括
标准化Solidago微光提取物 (EESM) 在暴露于尼古丁的高血压大鼠中显示出心脏保护作用. EESM减轻了脏和心血管损伤,表明其作为辅助疗法的潜力.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 心血管研究研究心血管研究
- 自然产品化学 自然产品化学
背景情况:
- 索里达戈微光 DC. (Asteraceae),被称为"巴西",传统上用于高血压和脏问题.
- 尼古丁暴露在自发高血压大鼠 (SHRs) 中加剧了心血管功能障碍.
- 了解天然提取物的心脏保护机制对于开发新的治疗策略至关重要.
研究的目的:
- 在大鼠模型中研究标准化Solidago微光提取物 (EESM) 的心脏保护作用.
- 评估EESM对尼古丁诱导的心血管和功能障碍在自发高血压大鼠 (SHRs) 的影响.
- 探索与EESM心血管影响相关的潜在分子机制.
主要方法:
- 在雌性Wistar大鼠中评估了EESM的急性毒性.
- 六个月大的男性SHRs被治疗以EESM (14,28,56毫克/公斤),甲酸盐或载体的不同剂量,以及28天的尼古丁暴露.
- 评估包括功能,心电图,血压,心室功能,生化标志物,血管反应能力,器官重量和心脏形态学.
主要成果:
- 尼古丁诱导显著的功能障碍,血压升高,改变了血管反应能力,在SHR中引发了左心室缩.
- 最高剂量的EESM (56 mg/kg) 有效地减轻了尼古丁诱导的所有脏和心血管变化.
- 治疗EESM使功能正常化,降低血压,改善心室功能,并预防心脏结构变化.
结论:
- 标准化Solidago微光提取物 (EESM) 具有显著的心脏保护和脏保护性质.
- 在高血压和尼古丁暴露的老鼠模型中,EESM证明了预防心血管功能障碍的有效性.
- EESM是增强心脏保护的辅助疗法的潜在候选者.
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