在不影响瘤结果的情况下维护功能:在T3期细胞癌中对部分和全切除术的比较研究
Ahmed Alasker1,2,3, Turki Rashed Alnafisah1, Mohammad Alghafees1
1College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Journal of kidney cancer and VHL
|January 1, 2024
概括
部分瘤切除术 (PN) 提供了与T3a细胞癌 (RCC) 激进瘤切除术 (RN) 相似的瘤结果. 这项研究发现,在T3a RCC患者中,PN和RN之间的复发率,转移率或存活率没有显著差异.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 部分切除术 (PN) 在治疗局部晚期T3期细胞癌 (RCC) 的作用仍在争论中.
- T3a RCC涉及已超出脏的瘤,但尚未扩散到上腺或淋巴结.
研究的目的:
- 评估pT3a阶段细胞癌 (RCC) 患者的部分切除术 (PN) 的瘤和功能结果.
- 为了比较PN与激进切除术 (RN) 在治疗pT3a RCC的疗效.
主要方法:
- 在2015年1月至2023年期间接受开放式,腹腔镜或机器人PN的pT3a RCC患者的回顾性分析.
- 使用威尔科克森等级总和测试对切除类型 (PN与RN) 的比较.
- 使用卡普兰-梅尔图和日志等级测试来评估局部复发,转移性进展和整体存活率的生存分析.
主要成果:
- 在PN和RN组之间,在局部复发率 (P = 0.597),转移性进展 (P = 0.129) 或化疗使用 (P = 0.367) 中没有发现显著差异.
- 根据切除术的类型,患者的存活率没有显著差异 (逻辑等级P值=0.852).
- 两组之间在年龄和体重指数方面发现了人口差异,但这些并没有影响生理结果.
结论:
- 部分切除术 (PN) 和彻底切除术 (RN) 在pT3a细胞癌 (RCC) 患者中显示出几乎相当的瘤结果.
- 对于pT3a RCC来说,PN是一种可行的和有效的治疗选择,在复发,转移和存活方面,它提供了与RN相似的结果.
- 研究结果支持在选定的pT3a RCC病例中考虑PN,平衡瘤控制与潜在的功能益处.
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