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手术是否会影响全身免疫反应? 进行TGF-β,IL-8和CD45RO的外科分析

Leah Trumet^1,2,3, Jutta Ries^1,2, Niclas Ivenz^1,2

¹Department of Oral and Cranio-Maxillofacial Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

Frontiers in oncology

|January 1, 2024

概括

在口腔状细胞癌患者中,大额口腔面部手术暂时降低了免疫生物标志物CD45RO,TGF-β和IL-8. 这些与手术持续时间相关的变化表明过渡性免疫抑制,而不是长期的全身影响.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
手术科学手术科学

背景情况:

增加口腔状细胞癌 (OSCC) 的免疫疗法选择需要了解手术对免疫反应的影响.
术后免疫生物标志物的动态对于优化OSCC治疗中的免疫治疗方案至关重要.

研究的目的:

在接受大额口腔面部手术的OSCC患者中研究CD45RO,TGF-β和IL-8的术后变化,与对照组对比.
分析这些免疫生物标志物变化与人口统计学/生物形态学参数之间的关联.

主要方法:

实时定量聚合酶链反应 (RT-qPCR) 分析了38名患者的CD45RO,TGF-β和IL-8的mRNA表达.
血液样本在五个时间点收集:手术前和手术后的第10天.
统计分析包括曼-惠特尼-U,威尔科克森测试和斯皮尔曼相关性.

主要成果:

在OSCC患者中,术后CD45RO,TGF-β和IL-8显著下调,直到术后4天.
与对照组相比,OSCC患者的TGF-β和IL-8的减少在OSCC患者中更为显著.
手术持续时间与这些免疫标记物的术前减少相关;在淋巴结转移的患者中,术前TGF-β较低.

结论:

大型头手术似乎具有暂时的,不持久的,全身免疫效应.
降低CD45RO可能表明术后的临时免疫抑制.
这些发现支持将手术持续时间降至最低,并探索结合的术后抗PD-1和抗TGF-β免疫疗法.

关键词:

在HNSCC中,我们可以看到HNSCC.这是OSCCCC的OSCC.细胞因子细胞因子它们包括interleukins和interleukins.口腔手术是口腔外科手术.在外科手术期间,信号通路的系统性变化免疫耐受性免疫耐受性手术手术手术手术手术手术手术

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