准备和评估黄衍生物纳米乳液基于黄提取物及其抗抑郁作用
Lin Sheng1,2,3,4, Yumeng Wei1,3, Chao Pi1,3
1Key Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy of Southwest Medical University, Luzhou, People's Republic of China.
International journal of nanomedicine
|January 1, 2024
概括
这项研究开发了一种黄提取物纳米输送系统 (TUR-NE),可显著提高生物可用性和抗抑郁作用. TUR-NE显示出作为一种新的治疗抑郁症的口服治疗方法的承诺,其安全性和有效性得到改善.
科学领域:
- 药理学 药理学是指药理学的学科.
- 纳米技术纳米技术
- 自然产品 自然产品
背景情况:
- 黄提取物 (TUR) 显示出抗抑郁药的潜力,其胺酸增强了这种潜力.
- 开发有效的输送系统对于改善TUR的药理动力学特征和治疗疗效至关重要.
研究的目的:
- 开发和描述黄提取物的纳米输送系统 (TUR-NE).
- 评估TUR-NE的增强的药理动力学行为和抗抑郁作用.
主要方法:
- 黄提取物 (TUR) 的表征和纳米输送系统 (TUR-NE) 的制造和优化.
- 在体外抗氧化和运输抑制测定,大鼠的药理学研究,和抑郁症 (CUMS) 的小鼠模型中的抗抑郁药疗效评估.
主要成果:
- 与黄素 (CU) 和素相比,TUR表现出更高的抗氧化能力和抑制ASP+运输.
- 图尔-内显示出最佳的纳米粒子特性 (116纳米大小,98.45%封装) 增强了稳定性和释放性.
- 药理动力学研究显示,与TUR和CU相比,TUR-NE的AUC和Cmax显著增加.
- 在CUMS小鼠中,TUR-NE显著缓解了抑郁行为,并增加了5西胺水平,安全性良好.
结论:
- 开发的 TUR-NE 系统有效地提高了 TUR 的生物可用性和抗抑郁作用.
- TUR-NE代表了一种有前途的新型口服制剂,用于治疗抑郁症.
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