评估维生素D作为炎症性肠病中的生物标志物
Fiona Yeaman1, Anke Nguyen1, Joshua Abasszade1
1Department of Gastroenterology and Hepatology Monash Health Clayton Victoria Australia.
血清维生素D水平与便calprotectin有负相关性,这表明维生素D可能作为炎症性肠病 (IBD) 活动的辅助生物标志物.
科学领域:
- 胃肠病学 胃肠病学
- 临床化学 临床化学
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠病 (IBD) 需要可靠的生物标志物来检测疾病活动.
- 在IBD患者中,维生素D缺乏是常见的,IBD患者有活跃的疾病.
- 血清维生素D在IBD患者的常规监测.
研究的目的:
- 评估血清维生素D作为IBD活动的潜在生物标志物在现实世界患者队列中.
- 调查维生素D水平与已确定的IBD活动标志物之间的相关性.
主要方法:
- 在3个月内对IBD患者具有可用的便calprotectin (FCP) 和维生素D水平的回顾性图表审查.
- 计算临床评分和分析其他血清生物标志物.
- 非参数统计测试,以评估维生素D,FCP和临床参数之间的相关性.
主要成果:
- 在所有IBD患者中,血清维生素D和FCP水平之间观察到显著的负相关性 (r = -0.19,P < 0.001).
- 较低的维生素D水平与较高的部分梅奥得分和性结肠炎中CRP/白蛋白比率有关.
- 低维生素D水平与克罗恩病中CRP和CRP/白蛋白比率升高相关.
结论:
- 血清维生素D水平与FCP呈负相关性,表明它有可能作为IBD的辅助生物标志物.
- 需要进一步的前性研究来探索维生素D与IBD中的其他炎症生物标志物之间的关系.
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