血代谢分析表明,L-氨酸补充剂会影响微生物活动,导致三甲基胺N-氧化物减少 - - 一项随机对照试验,针对有心脏代谢风险因素的超重健康成年人进行
Laurianne Dimina1, Marie Tremblay-Franco2,3, Ambre Deveaux1
1Université Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, Palaiseau, France.
Current developments in nutrition
|January 1, 2024
概括
补充L-氨酸 (L-arg) 影响人类的新陈代谢,影响氨基酸和减少三甲基胺N-氧化物 (TMAO),表明肠道微生物群活动和甲基平衡发生变化.
科学领域:
- 代谢学 代谢学 代谢学
- 人类营养人类营养
- 心脏代谢健康状况
背景情况:
- 氨酸 (L-arg) 以其在氧化 (NO) 生产中的作用以及对血管和心脏代谢健康的影响而闻名.
- 除了NO之外,L-的更广泛的代谢作用尚未完全理解,这是由于复杂的氨酸代谢.
研究的目的:
- 为了研究低剂量,持续释放的L-arg补充剂对人类整体新陈代谢的影响.
- 在禁食和食后状态中评估代谢变化,特别是在全静态压力因素 (高脂肪餐) 后.
主要方法:
- 一项随机,双盲,交叉研究,涉及32名患有心脏代谢风险因素的健康超重成年人.
- 参与者接受了持续释放L-arg (4.5g/d) 或安慰剂4周.
- 使用液态染色体质谱法对高脂肪餐挑战前后采集的血样本进行代谢分析.
主要成果:
- 高脂肪饮食挑战显著改变了新陈代谢.
- 补充L-解释了总代谢变异的小但显著部分 (0.5%).
- 关键发现包括L-arg治疗下氨基酸 (包括分支链氨基酸) 和三甲基胺N氧化物 (TMAO) 的水平降低,这表明甲基需求增加.
结论:
- 四周的L-补充剂会影响甲基平衡和肠道微生物群活动,由降低的TMAO水平表明.
- 这些发现突出了L-arg作用的潜在非NO介导机制.
- 需要进一步的研究来探索这些代谢变化的长期健康影响.
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