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相关概念视频

Volatilization01:10

Volatilization

392
Volatilization gravimetry is an analytical technique that measures the mass lost due to the volatilization of the substance. This technique is used to estimate the amount of volatile material in a sample. To perform this method, heat a known amount of the sample to a high temperature in a crucible or other suitable vessel. The volatile substance in the sample evaporates, and the vapor is completely expelled from the crucible either by heating the sample or bubbling a stream of inert gas through...
392
Measuring Reaction Rates03:09

Measuring Reaction Rates

25.1K
Polarimetry finds application in chemical kinetics to measure the concentration and reaction kinetics of optically active substances during a chemical reaction. Optically active substances have the capability of rotating the plane of polarization of linearly polarized light passing through them—a feature called optical rotation. Optical activity is attributed to the molecular structure of substances. Normal monochromatic light is unpolarized and possesses oscillations of the electrical...
25.1K
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

515
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
515

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相关实验视频

Updated: Jul 6, 2025

Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis
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Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis

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用于估计代谢物挥发性的自动化方法.

Laura K Meredith1,2, S Marshall Ledford3, Kristina Riemer4

  • 1School of Natural Resources and the Environment, University of Arizona, Tucson, AZ, United States.

Frontiers in microbiology
|January 1, 2024
PubMed
概括
此摘要是机器生成的。

一个新的管道,volcalc,估计了代谢物挥发性,揭示了对生物作用和挥发性的洞察力. 这个工具有助于理解整个生命周期的挥发性化合物.

关键词:
挥发性有机化合物 挥发性有机化合物生物信息学是一种生物信息学.化学信息学 化学信息学代谢数据库的代谢数据库.挥发性代谢产物是挥发性的代谢产物.波动性 波动性的波动性

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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

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相关实验视频

Last Updated: Jul 6, 2025

Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis
11:25

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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

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科学领域:

  • 代谢学 代谢学 代谢学
  • 化学信息学 化学信息学
  • 系统生物学 系统生物学

背景情况:

  • 代谢物挥发性影响生物功能和检测方法.
  • 对于许多代谢物的挥发性数据很少,这阻碍了研究.
  • 了解挥发性是探索代谢物作为基本生物特征的关键.

研究的目的:

  • 开发一种自动化方法来估计代谢物挥发率.
  • 为了创建一个开放的管道,volcalc,用于预测气相分离.
  • 分析生物系统中挥发性代谢物的分布和重要性.

主要方法:

  • 适应SIMPOL.1方法来估计分子功能组的蒸汽压力.
  • 实现了使用化学信息工具进行自动估计的Volcalc管道.
  • 利用基因和基因组的京都百科全书 (KEGG) 数据库来获取代谢物数据.

主要成果:

  • 与精选数据相比,在预测波动类别方面获得了93%的准确性.
  • 估计3.4% (土壤) 到26.6% (清洁大气) 的KEGG化合物是高度挥发性的.
  • 确定了所有生命领域的30%共享挥发物的核心集合,其中细菌具有最具王国特异性的挥发物.

结论:

  • 沃尔卡克为研究挥发体和挥发性代谢产物作用提供了基础.
  • 该管道有助于在生物系统中产生和测试假设.
  • 沃尔卡克是一个可访问的工具,可以将波动性分析与其他生物信息学管道相结合.