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生物相容的光学物理非克隆功能凝微粒用于剂量认证.

Mengmeng Zhang1, Aparna Raghunath1, An Zhao1

  • 1Process & Energy Department, Delft University of Technology, Leeghwaterstraat 39, 2628 CB Delft, the Netherlands.

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概括
此摘要是机器生成的。

这项研究引入了定剂量物理非克隆功能 (PUF) 用于制药认证,将微球嵌入水凝中,以创建独特的药物指纹. 这种新的方法允许患者使用手机验证药物,提高药物安全性并防止假冒.

关键词:
打击假冒和伪造的行为生物相容性 生物相容性体体是一种体.这是一种乳液乳液.水凝是一种水凝.在剂量认证时的认证.有光学PUF可以使用.物理上的不可克隆的功能.

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科学领域:

  • 制药科学 制药科学
  • 材料科学 材料科学 材料科学
  • 密码学 密码学 密码学 密码学

背景情况:

  • 剂量认证 (ODA) 使用独特的标签来防止假冒药物.
  • 图形物理不可克隆功能 (PUF) 提供高安全性,但由于毒性和特定的成像需求,在药物应用中存在局限性.
  • 现有的方法与非复制和逆向工程挑战作斗争.

研究的目的:

  • 开发一种新的按剂量PUF系统,用于药品认证.
  • 创建一种安全,无毒,易于实施的方法来验证药物的真实性.
  • 使患者能够使用移动电话等可访问技术来验证药物的真实性.

主要方法:

  • 在生物相容的水凝颗粒中随机嵌入微球 (超级磁性合体或油滴),以创建独特的药物指纹.
  • 使用微球直径和坐标作为加密密钥生成的输入.
  • 采用通用圆圈识别和捆绑程序来提取数据.
  • 使用白光照明和低放大显微镜验证系统.

主要成果:

  • 证明了两种类型的按剂量使用的PUF:一种是用超对磁性合物,另一种是用向日油滴.
  • 单直径系统成功通过了NIST统计测试,显示出足够的随机性,位统一性和设备独特性.
  • 该系统可通过手机进行身份验证,只需要白光和低放大图像.
  • 单直径系统的编码能力为,这表明了显著的标签潜力.

结论:

  • 拟议的按剂量PUF方法为药品认证提供了安全,用户友好和经济有效的解决方案.
  • 这项技术克服了当前图形PUF的局限性,使其适合广泛用于制药领域.
  • 定剂量PUF有潜力显著提高药物安全性,保护患者免受假冒药物的侵害,并改善供应链完整性.