社会威胁安全测试揭示了与社会心理压力相关的现象
Sarah Ayash1, Marianne Müller2, Ulrich Schmitt3
1Leibniz-Institute for Resilience Research.
Journal of visualized experiments : JoVE
|January 1, 2024
概括
这项研究改进了老鼠的慢性社会失败 (CSD) 压力,以更好地模拟人类的精神障碍. 一个新的社会威胁安全测试 (STST) 通过评估社会回避行为来区分压力弹性和易感性.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 精神病学是一个精神病学.
背景情况:
- 社会压力是精神障碍发展的关键因素.
- 临床前模型需要增强人类相关性的翻译有效性.
- 慢性社会失败 (CSD) 是对压力诱导的精神功能障碍的小鼠模型.
研究的目的:
- 为更强的心理社会组成部分完善CSD协议.
- 为详细的行为评估引入社会威胁安全测试 (STST).
- 将CSD小鼠分为弹性和易受影响的子组.
主要方法:
- 一个为期10天的CSD协议,具有标准化的攻击和感官阶段.
- 引入使用新的社会目标的社会威胁安全测试 (STST).
- 同时评估社会回避,威胁安全歧视和厌恶性学习.
主要成果:
- STST有效地衡量了社会回避和威胁安全歧视.
- 对两个目标菌株的社会回避的发展表明了对压力的敏感性.
- 仅避免攻击性菌株表明应激弹性.
结论:
- 改进的CSD和STST协议为压力研究提供了更好的翻译价值.
- 这种方法可以准确地分类小鼠的应激弹性和易感性.
- 推进人类情感障碍的临床前模型.
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