世界贸易中心的正常肺功能和死亡率响应者和国家健康和营养检查调查III参与者参与者
Madeline F Cannon1,2, David G Goldfarb1,2,3, Rachel A Zeig-Owens1,2,3
1Department of Medicine, Montefiore Medical Center, Bronx, New York.
American journal of respiratory and critical care medicine
|January 1, 2024
概括
一秒内强制呼气量 (FEV1) 的增加与死亡风险的降低有关,即使肺功能正常. 这项研究表明,FEV1预测了长期存活率,强调其作为健康指标的作用.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 生物标志物 生物标志物
背景情况:
- 一秒内低强制呼气量 (FEV1) 是已知的增加死亡率的预测因素.
- 正常肺功能 (预测FEV1≥80%) 与死亡率之间的关系尚未得到充分确立.
研究的目的:
- 调查FEV1与正常肺功能个体的全因死亡率之间的关联.
- 为了确定FEV1,即使在正常范围内,也可以作为长期生存的预后指标.
主要方法:
- 对纽约市消防局 (FDNY) 10,999名应急人员和国家健康和营养检查调查 (NHANES III) 10,901名参与者 (年龄在18-65岁之间) 的分析,预测FEV1≥80%.
- 预测的FEV1%是使用全球肺功能倡议 (GLI) 的种族中立参考方程计算的.
- 与国家死亡指数相关的死亡数据;用于评估FEV1死亡关联的Cox比例危险模型,平均随访时间为20.3年.
主要成果:
- 在FEV1预测为80-89%和90-99%的个体中,与FEV1预测为≥120%的个体相比,观察到更高的死亡率.
- 预测FEV1每增加10%都与15% (FDNY) 和23% (NHANES III) 的死亡率降低有关.
- 一个单一的横截面FEV1测量预测了在20年内死亡率,即使在正常范围内.
结论:
- 在正常范围内的高FEV1与职业和一般人群中所有原因死亡率的降低有关.
- FEV1是整体健康和长期存活的强大生物标志物,超出了它在检测肺部疾病方面的既定作用.
- 这些发现强调了FEV1测量在临床实践中预测死亡风险的预后价值.
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