用稀土元素对蛋白质进行调制,作为生物技术工具
Azam Bakhti1, Zahra Shokouhi1, Fatemeh Mohammadipanah2
1Department of Microbial Biotechnology, Center of Excellence in Phylogeny of Living Organisms, College of Science, University of Tehran, 14155-6455 Tehran, Iran.
International journal of biological macromolecules
|January 1, 2024
概括
由于其独特的特性,稀土元素 (REEs) 在成像和癌症治疗等生物医学应用中表现有前途. 需要进一步的研究来探索所有REEs.
科学领域:
- 生物技术和生物医学科学
- 材料科学 材料科学 材料科学
- 毒理学 毒理学 毒理学
背景情况:
- 稀土元素 (REEs) 具有独特的光和氧化还原稳定性,磁性和光学性能,使其在生物成像中具有价值.
- REEs与蛋白质等宏分子相互作用,影响它们的功能和调节活动,从而导致各种生物医学应用.
- 兰化物复合物,REEs的一个子集,正在探索抗生物膜,抗癌,抗炎,药物输送和治疗作用.
研究的目的:
- 概述稀土元素 (REE) 在生物技术中的新兴应用,重点是生物医学成像,瘤诊断和治疗.
- 要突出与生物医学领域的REE利用相关的潜在毒性影响.
- 确定17个生物技术 REE 的全部潜力的研究缺口,并注意到大多数元素的研究有限.
主要方法:
- 对生物技术和生物医学应用中稀土元素 (REEs) 现有研究的文献综述.
- 分析报告的应用,包括生物成像,癌症治疗,药物输送和组织工程.
- 讨论REEs的毒理方面和环境行为.
主要成果:
- 由于其有利的物理化学特性,REEs越来越多地应用于生物成像,瘤诊断和治疗.
- 具体应用包括抗生物膜剂,癌症抑制剂,炎症调节剂以及药物输送和组织工程中的组件.
- 目前的研究主要集中在欧 (Eu), (Ce),加多 (Gd) 和兰 (La) 上,对其他可再生能源的探索有限.
结论:
- 在利用生物技术中的REEs方面取得了重大进展,特别是在生物医学成像和治疗方面.
- 需要对所有可再生能源的生态毒理学,环境命运和生物功能进行全面研究.
- 进一步的研究是必要的,以充分理解和利用整个REE集团在健康和疾病方面的潜力.
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