在儿童结核病诊断方面有什么新鲜事?
Camilla Rodrigues1, Tanu Singhal2
1Department of Microbiology & Infection Prevention Control, Hinduja Hospital, Mahim, Mumbai, India.
Indian journal of pediatrics
|January 1, 2024
概括
近一半的儿童结核病例没有被诊断出来,阻碍了全球消除的努力. 最近的诊断进步,包括新的分子测试和成像,为改善儿童结核病检测率提供了希望.
科学领域:
- 儿童传染病 儿童传染病
- 诊断技术 诊断技术 诊断技术
- 全球卫生健康 全球卫生健康
背景情况:
- 未诊断的儿童结核病 (TB) 影响全球近50%的病例,阻碍了结核病消除目标.
- 儿童结核病仍然存在重大诊断差距,需要创新的解决方案.
研究的目的:
- 审查儿童结核病诊断工具的最新进展.
- 突出这些新技术的潜力,以解决儿童结核病的诊断差距.
主要方法:
- 对儿童结核病新兴诊断技术的审查.
- 分析成像 (CXR,POCUS,CT/MRI),分子测定 (Xpert Ultra,Xpert XDR,测序) 和临床检测 (尿液LAM,C-Tb皮肤检测) 的进展.
主要成果:
- 新的成像技术和分子分析显示,结核病检测的灵敏度和特异性有所提高.
- 尿液LAM和Xpert XDR等临床检测提供了快速诊断,特别是在人类免疫缺陷病毒 (HIV) 同感染的儿童中.
- 替代样品类型 (便,鼻吸入物) 正在出现用于胸内结核病诊断.
结论:
- 对于儿童结核病,有几项有前途的诊断进展已经可用或正在开发中.
- 紧急将这些新型诊断策略集成到当前的儿科结核病管理算法中,对于改善病例检测和实现全球结核病消除至关重要.
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