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贝叶斯第二阶段自适应随机化通过联合建模有效性和毒性作为时间到事件结果

Yu-Mei Chang1, Pao-Sheng Shen1, Chun-Ying Ho1

  • 1Department of Statistics, Tunghai University, Taichung, Taiwan.

Journal of biopharmaceutical statistics
|January 2, 2024
PubMed
概括

这项研究为II期临床试验引入了一种新的贝叶斯适应性随机化 (BAR) 程序. 这种新方法通过将疗效和毒性作为时间到事件结果的联合建模来改善治疗分配,从而提高患者的安全性和试验效率.

关键词:
贝叶斯适应性随机化的贝叶斯随机化第二阶段试验试验.脆弱 脆弱 脆弱 脆弱 脆弱随机效应是一种随机效应.时间到事件的结果.毒性的毒性 毒性的毒性

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