针对免疫微环境进行卵巢癌治疗
Felix Blanc-Durand1,2, Lai Clemence Wei Xian1,2, David S P Tan1,3
1Department of Haematology-Oncology, National University Cancer Institute, Singapore (NCIS), National University Hospital, Singapore, Singapore.
Frontiers in immunology
|January 2, 2024
概括
卵巢癌 (OC) 具有免疫抑制性瘤微环境 (TME),阻碍免疫检查点抑制剂. 了解OC TME对于开发针对免疫逃避策略的有效免疫疗法至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 卵巢癌 (OC) 的特征是复杂的,免疫抑制的瘤微环境 (TME).
- 现有的免疫检查点抑制剂 (ICI) 在OC中表现出有限的疗效,缺乏患者分层的生物标志物.
- 了解OC TME对于开发新型免疫治疗策略至关重要.
研究的目的:
- 审查目前对卵巢癌瘤微环境 (TME) 的理解.
- 探索OC TME作为免疫疗法的治疗点的潜力.
- 讨论克服OC免疫逃避的挑战和机会.
主要方法:
- 关于卵巢癌免疫学和免疫治疗研究的文献综述.
- 对OC TME的细胞和分子组件的分析.
- 检查OC细胞使用的免疫逃避机制.
主要成果:
- 在OC TME中包含抗瘤免疫细胞 (TILs,B细胞,M1巨细胞,NK细胞) 和免疫抑制细胞 (Tregs,M2巨细胞,MDSCs).
- OC细胞采用多种策略来诱导免疫耐受性并逃避免疫监测.
- 标准PD-1/PD-L1抑制剂的成功程度有限,这表明需要更广泛的免疫检查点向.
结论:
- 由于其固有的免疫抑制性质,OC TME对有效的免疫疗法构成重大障碍.
- 针对多个免疫检查点和采用像采用细胞疗法和疫苗这样的新方法是有前途的.
- 根据个人OC免疫特征量身定制的个性化免疫治疗策略对于临床成功至关重要.
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