跨国公司在动脉样硬化和药物开发机会中的作用
Wujun Chen1, Yanhong Wang1, Chunling Ren2
1Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao, Shandong, 266071, China.
International journal of biological sciences
|January 2, 2024
概括
素C (TNC) 在动脉样硬化中过度表达,使其成为药物输送的目标. 针对TNC的几种载体显示出开发有效动脉样硬化治疗的希望.
科学领域:
- 心血管研究研究心血管研究
- 药物输送系统 药物输送系统
- 分子生物学分子生物学
背景情况:
- 素C (TNC) 是一种细胞外基质糖蛋白,在动脉样硬化中具有双重作用.
- TNC,特别是它的C域 (TNC-C),在活性动脉样硬化斑块中高度表达.
- 这种过度表达表明TNC是一种可行的动脉样硬化特异性药物输送目标.
研究的目的:
- 审查TNC在动脉样硬化中的作用.
- 讨论针对动脉样硬化的TNC的药物输送载体.
- 探索针对TNC的药物开发,以改善治疗结果.
主要方法:
- 在动脉样硬化中对TNC研究的文献综述.
- 分析各种针对TNC的药物输送载体 (例如G11,TN11,PL1,F16).
- 检查正在开发或临床试验中的针对TNC的治疗剂和疫苗.
主要成果:
- 包括G11-iRGD和PL1在内的几种TNC绑定载体显示出显著的潜力.
- 此外,PL1还向纤维素蛋白的额外域-B (EDB),这是另一种动脉样硬化标志物.
- 针对TNC的药物如F16IL2,ATN-RNA和IMA950正在临床试验中.
结论:
- 向Tenascin C提供了一个有希望的策略,以提高动脉样硬化向药物的疗效.
- 开发TNC特定的传递载体和药物可以显著提高动脉样硬化治疗成功率.
- 进一步研究基于TNC的疗法是有效的动脉样硬化管理的必要条件.
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