作为预后指标,IGFBP5促进瘤进展,并与质瘤中的免疫微环境相关
Jiediao Lin1,2, Guowei Huang3, Qianru Zeng1
1Central laboratory, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China.
Journal of Cancer
|January 2, 2024
概括
胰岛素样生长因子结合蛋白5 (IGFBP5) 是质瘤中的一种瘤基因,预测预后不佳,与免疫细胞透相关. 它影响瘤的进展,并可能作为一个有价值的生物标志物.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 胰岛素样生长因子结合蛋白5 (IGFBP5) 在各种癌症中升高,包括质瘤.
- IGFBP5在质瘤发病过程中的特定作用及其预后意义尚不清楚.
研究的目的:
- 调查IGFBP5作为质瘤的预后生物标志物.
- 分析IGFBP5表达与质瘤中的免疫透之间的关联.
主要方法:
- 使用TCGA,CGGA,Rembrandt和Gravendeel数据库进行临床数据分析.
- 进行了生存分析,ROC曲线,Cox回归和丰富分析.
- 进行了体外测定 (CCK8,殖民地形成,划痕,穿孔) 和免疫组织化学测定,以评估IGFBP5的功能和表达.
主要成果:
- 较高的IGFBP5水平与较高的质瘤恶性相关,并预测不良结果.
- IGFBP5的表达与B细胞,T细胞,巨细胞和NK细胞的透显著相关.
- IGFBP5影响质瘤细胞的增殖,迁移,入侵和PD-L1/CXCR4表达,可能通过EMT和Hippo-YAP途径.
结论:
- IGFBP5在质瘤中起到瘤基因的作用.
- IGFBP5是一种有价值的生物标志物,用于预测质瘤预后和免疫透.
- IGFBP5与质瘤的进展和免疫调节有关.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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