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与子宫内膜癌预后相关的营养指数

Yuki Gen¹, Jisu Yun¹, Jimin Ahn²

¹Department of Obstetrics and Gynecology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

International journal of medical sciences

|January 2, 2024

概括

预后营养指数 (PNI) 较低表明子宫内膜癌 (EC) 患者的结果较差. 这种营养标志物可以帮助预测复发和生存,帮助临床决策.

科学领域:

在瘤学瘤学.
营养科学营养科学
生物统计学生物统计学

背景情况:

子宫内膜癌 (EC) 是一种严重的妇科恶性瘤.
确定可靠的预后标志物对于患者管理至关重要.
预后营养指数 (PNI) 反映了营养状况和免疫功能.

研究的目的:

在被诊断为子宫内膜癌 (EC) 的患者中评估预后营养指数 (PNI) 的预后价值.
确定PNI是否可以预测EC患者的复发和存活率.

主要方法:

从370名EC患者 (2010-2021) 的实验室和临床病理学数据的回顾性分析.
计算PNI并分析其与复发和整体存活时间 (OS) 的相关性.
接收器操作特征 (ROC) 曲线分析以确定最佳PNI切线值和Cox比例危险模型用于预测因素分析.

主要成果:

确定了52.74的最佳PNI截止值,用于无病生存期 (DFS).
与高PNI组 (p < 0.001) 相比,低PNI组患者的复发率 (30.6%对5.2%) 和与癌症有关的死亡率 (17.8%对2.8%) 与高PNI组相比显著更高 (p < 0.001).
多变量分析证实PNI是EC患者中DFS和OS的独立预后因素.

结论:

预后营养指数 (PNI) 较低与子宫内膜癌 (EC) 患者的临床结果较差显著相关,包括复发和死亡率增加.
普尼显示出作为EC临床可靠和有用的预后标志物的潜力.
需要进一步的大规模前性研究来验证这些发现.

关键词:

在 PNI PNI 中.这是子宫内膜癌的癌症.预后因素预后因素预后营养指数的预后.这是子宫癌,子宫癌.

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