在儿科IBD患者中,Infliximab早期的最低水平预测了持续的缓解
Nanja Bevers1, Arta Aliu2, Dennis R Wong3
1Department of Paediatrics, Zuyderland Medical Center, Dr. H. van der Hoffplein 1, 6162 BG Sittard, The Netherlands.
在儿科炎症性肠病 (IBD) 患者中,在第14周测量infliximab的最低水平至关重要. 6.9 mg/L的目标水平最能预测持续缓解,优化治疗结果.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 药理动力学 药理动力学
- 免疫调节疗法是一种免疫调节疗法.
背景情况:
- 较高的INFLIXIMAB度与炎症性肠病 (IBD) 的改善结果相关.
- 在儿科IBD患者中测量INFLIXIMAB水平的最佳时间尚不清楚.
研究的目的:
- 为了确定在第6周或第14周的低谷水平是否预测了儿科IBD的持续缓解.
- 在第6周和第14周为infliximab建立目标低谷水平.
主要方法:
- 从70名先前没有抗瘤缩因子的儿科IBD患者的电子医疗数据的回顾性分析.
- 在每剂量之前测量因弗力西马布的最低水平和疾病活性标志物.
- 持续缓解定义为从第26周到第52周没有症状和低炎症标志物.
主要成果:
- 在获得持续缓解的患者中,第14周的Infliximab水平显著更高 (7.7 mg/L与3.8 mg/L,p=0.006).
- 接受器操作特征分析表明,14周水平 (AUC 0.75) 比6周水平 (AUC 0.67) 更好地预测缓解.
- 最佳目标低谷水平在第6周被确定为13.2毫克/升,在第14周为6.9毫克/升.
结论:
- 在第14周测量Infliximab的最低水平是儿科IBD持续缓解的有价值预测指标.
- 建议在第14周达到6.9毫克/升的目标最低水平,以优化治疗反应.
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