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Updated: Jul 6, 2025

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
15:05

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

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一种构成性EGFR激酶消耗剂,用于研究抑制剂药理学

Justin J Kim1, Ilse K Schaeffner1, David E Heppner1

  • 1Department of Cancer Biology (J.J.K., I.K.S., T.S.B., M.J.E.), Lowe Center for Thoracic Oncology (C.T., P.A.J.), and Department of Medical Oncology (C.T., P.A.J.), Dana-Farber Cancer Institute, Boston, Massachusetts; Department of Biological Chemistry and Molecular Pharmacology (J.J.K., I.K.S., T.S.B., M.J.E.) and Department of Medicine (C.T., P.A.J.), Harvard Medical School, Boston, Massachusetts; Department of Chemistry, University at Buffalo, Buffalo, New York (D.E.H.); Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, New York (D.E.H.).

Molecular pharmacology
|January 2, 2024
PubMed
概括

研究人员开发了一种稳定的表皮生长因子受体 (EGFR) 激酶二聚体,以研究药物如何对抗肺癌. 这一工具有助于了解异质抑制剂对抗耐药EGFR变异的有效性.

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