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释放未分化诱导多能干细胞生物打印的力量:目前的进展和未来的前景

Boyoung Kim¹, Jiyoon Kim¹, Soah Lee^1,2

¹Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon, Korea.

International journal of stem cells

|January 2, 2024

概括

3D生物打印为创建复杂诱导多能干细胞 (iPSC) 组织提供了可扩展的解决方案,克服了再生医学和疾病研究当前3D模型的局限性.

科学领域:

生物技术是生物技术.
再生医学是一种再生医学.
干细胞生物学干细胞生物学

背景情况:

诱导多能干细胞 (iPSC) 技术已经推进了干细胞研究,疾病建模和再生医学.
从2D到3D iPSC模型 (球体,有机体) 的过渡提供了更大的生理相关性.
当前的3D模型面临复杂几何,死核,可扩展性和可重复性方面的挑战.

研究的目的:

审查诱导多能干细胞 (iPSCs) 3D生物打印的当前趋势和进展.
探索3D生物打印的潜力,以弥合传统iPSC模型和体内组织之间的差距.
突出生物打印用于创建具有可扩展性和可重复性的复杂3D组织和器官的应用.

主要方法:

对3D生物打印的基本概念和技术的审查.
对iPSC应用的生物墨设计原则的分析.
检查生物打印不分化的iPSC的最新研究进展.

主要成果:

3D生物打印可以开发复杂的3D组织和器官.
这项技术为基于iPSC的模型提供了高的可扩展性和可重复性.
生物打印解决了现有的3D iPSC模型的局限性,例如几何复杂性和死核核心.

结论:

3D生物打印是一种革命性的技术,用于在再生医学和疾病建模中推进iPSC应用.
需要继续进行研究,以克服现有的局限性,并充分实现iPSC生物打印的潜力.
未来的前景包括创建更复杂和功能性的iPSC衍生组织和器官.

关键词:

在3D生物打印中使用3D生物打印诱导的多能干细胞干细胞组织工程是组织工程.

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