三种新的抗炎性 stilbenoids 和一个来自Cajanus cajan的二乙烯衍生物
Liyuan Yao1,2,3, Xiaobao Huang1,4, Tingting Lin1
1State Key Laboratory of Plant Diversity and Specialty Crops & Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China.
Natural product research
|January 2, 2024
概括
研究人员从Cajanuscajan叶子中分离出了新的化合物,包括新型和双. 两种化合物通过抑制巨细胞中氧化的产生,显示出中度的抗炎活性.
科学领域:
- 植物化学 植物化学
- 自然产品 化学 化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 豆 (Cajanus cajan) 是一种广泛种植的豆类,具有传统药用历史.
- 凯扬 (Cajanus cajan) 的化学成分,特别是它的叶子,尚未完全阐明.
- 自然产品是发现新治疗剂的重要来源.
研究的目的:
- 从Cajanuscajan叶子的乙醇提取物中分离和描述新的化学化合物.
- 调查分离的化合物的潜在抗炎性质.
主要方法:
- 使用色谱技术提取和分离化合物.
- 使用广泛的光谱方法 (UV,IR,1D/2D NMR,HRESIMS) 阐明结构.
- 在体外抗炎测定使用脂聚糖 (LPS) 刺激的RAW 264.7巨细胞来测量氧化 (NO) 生产.
主要成果:
- 分离了三个新型的 stilbenoid:cajananthrenes A 和 B (phenanthrenes),cajanbenzyl (bibenzyl) 和cajanether (二乙烯).这三种新型的 stilbenoid 的分离方法是:Cajananthrenes A 和 B (phenanthrenes),Cajanbenzyl (bibenzyl),以及Cajanether (diphenyl ether).
- 识别了五种已知的化合物 (5-9).
- 甲和乙具有适度的抗炎活性,抑制了NO的产生,IC50值分别为73.6μM和44.6μM.
结论:
- 这项研究成功地确定了来自Cajanus cajan.的新型,双和二乙醇衍生物.
- 甲和乙呈现出有前途的抗炎作用,需要进一步研究.
- 对1-3化合物的拟议生物发生途径为人们提供了对它们自然合成的见解.
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