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IL-17A作为一种新的循环生物指标,用于非小细胞肺癌诊断和预后

J-X Wang¹, X-J Xu, Z-M Zhu

¹Department of Thoracic Surgery, The First Affiliated Hospital of Xingtai Medical College, Xingtai, Hebei Province, China. xtliushiwei@163.com.

European review for medical and pharmacological sciences

|January 2, 2024

概括

介素-17A (IL-17A) 显示为非小细胞肺癌 (NSCLC) 的生物标志物具有前途. 升高的IL-17A水平可以帮助早期诊断,并预测NSCLC患者的预后不佳.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学

背景情况:

肺癌 (LC) 是全球癌症死亡的主要原因.
非小细胞肺癌 (NSCLC) 约占LC病例的85%.
缺乏敏感的生物标志物导致晚期诊断和NSCLC的不良结果.

研究的目的:

调查介素-17A (IL-17A) 作为NSCLC患者的诊断和预后生物指标的作用.
为了比较IL-17A的疗效与现有的生物标志物,如癌胚抗原 (CEA).

主要方法:

循环IL-17A水平使用酶相关免疫吸收试验 (ELISA) 来量化.
用接收器操作特征 (ROC) 曲线分析来评估诊断准确性.
预测值是通过Kaplan-Meier分析来评估的.

主要成果:

与对照组相比,NSCLC患者的循环IL-17A水平显著升高.
在测试和验证队列中,IL-17A在CEA上表现出优越的诊断性能.
升高的IL-17A水平与更差的预后相关,并准确预测了早期NSCLC.

结论:

循环IL-17A作为NSCLC的强大和可靠的诊断生物指标.
IL-17A是一种有价值的预后标志物,表明NSCLC患者的结果更差.
IL-17A有可能改善NSCLC的早期检测和患者管理.

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