作为预测慢性胰腺炎患者心血管风险的阿波利波蛋白
M Kovacheva-Slavova1, J Genov, B Golemanov
1Department of Gastroenterology, University Hospital "Tsaritsa Ioanna-ISUL", Medical University of Sofia, Sofia, Bulgaria. kovacheva_mila@abv.bg.
患有慢性胰腺炎的患者心血管风险较高. 脂蛋白水平,特别是脂蛋白B和A-I,可以帮助预测这种风险,特别是在男性中. 对于专门的查小组,需要进一步的研究.
科学领域:
- 心血管医学 心血管医学
- 胃肠病学 胃肠病学
- 生物化学 生化学
背景情况:
- 患有慢性胰腺炎的患者面临心血管事件风险升高.
- 脂蛋白是动脉动脉生成的关键,可以改善心血管风险 (CVR) 的预测.
- 了解慢性胰腺炎的CVR因素对于患者管理至关重要.
研究的目的:
- 在被诊断患有慢性胰腺炎的患者中调查心血管风险因素.
- 评估各种阿波利波蛋白形式在预测该队列中CVR中的作用.
- 为了将阿波利波蛋白水平与已确定的风险得分和胰腺炎严重程度相关联.
主要方法:
- 招募了70名慢性胰腺炎患者,这些患者患有外分泌功能不充分.
- 使用阿波利波蛋白 (A-I,A-II,B,C-III),脂质样本和风险评分 (SCORE,弗雷明汉风险评分) 评估CVR.
- 使用M-ANNHEIM分类的慢性胰腺炎和使用SPSS v. 22分析的数据.
主要成果:
- 低的阿波利波蛋白A-I和高的阿波利波蛋白B水平是常见的,这表明有风险性潜在的增加.
- 45.71%的男性表现出高心肌梗塞风险,与阿波利波蛋白B/A-I比率升高有关;男性面临更高的心血管回血率.
- 阿波利波蛋白A-I/A-II与高血压相关;B/C-III与LDL,TC,TG相关. 较高的胰腺炎严重程度与较差的阿波利波蛋白样本相关.
结论:
- 脂蛋白是慢性胰腺炎患者心血管风险的重要指标.
- 这些发现表明,阿波利波蛋白可以被纳入CVR查中.
- 建议进行进一步的研究,为这一群体建立一个特定的CVR查小组.
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