中国牛群的温度适应模式由TRPM2基因突变分析揭示
Dekai Liu1, Yifan Yang1, Zhefu Chen1
1Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A and F University, Yangling, China.
Animal biotechnology
|January 2, 2024
概括
在TRPM2基因的特定突变有助于牛适应热量. 具有这种突变的南方牛品种表现出更好的耐热性,有助于在气候变化中进行畜牧管理.
科学领域:
- 动物遗传学动物遗传学
- 环境生理学环境生理学
- 分子生物学分子生物学
背景情况:
- 牛很容易受到热应激,这会影响畜牧业的生产.
- TRPM2基因在感知温度变化和响应热应激方面发挥作用.
- 了解遗传适应对于在不同气候下养牛至关重要.
研究的目的:
- 研究TRPM2基因突变 (c.805A>G:p.Met269Val) 在中国牛适应温度的功能作用.
- 分析TRPM2基因型与环境温度参数之间的关联.
主要方法:
- 利用牛基因组变异数据库 (BGVD) 识别TRPM2基因中的错误突变.
- 来自20个中国品种的407头牛在各种气候区进行基因定型.
- 使用三个温度参数和TRPM2基因型数据进行了关联分析.
主要成果:
- 在TRPM2基因中发现了一个误解突变 (rs527146862).
- 在中国北方和南方的牛品种之间观察到TRPM2 (A与G) 的明显的等位基频率分布.
- 在南方牛群中发现了显著更高的GG和GA基因型频率 (P<0.01),表明增强了热度适应.
结论:
- TRPM2基因型 (AA,GA,GG) 与环境温度参数有显著的相关性.
- 在TRPM2中异体 (GA) 和同体 (GG) 突变增加了对高温的适应性.
- 研究结果为战略性牛品种选择提供了遗传见解,以改善气候适应性和畜牧业生产.
相关概念视频
02:27Background and Environment Affect Phenotype
6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K
02:45Responses to Heat and Cold Stress
13.5K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
13.5K