用局部聚氨酸和氨的利用用于治疗高颗粒组织的治疗
Kimberly Brown Maynell1, William West2, Jenna Marek2
1Department of Plastic Surgery, University of South Florida, Tampa, FL 33606, USA.
概括
一种新型的局部类固醇奶油有效地治疗烧伤中的高颗粒组织. 这种治疗方法是50/50的氨和聚氨酸混合物,为管理这种常见的伤口并发症提供了安全有效的替代方案.
科学领域:
- 伤口愈合 治愈 伤口愈合
- 烧伤护理 烧伤护理
- 皮肤病学 皮肤病学
背景情况:
- 过度颗粒组织是颗粒组织的异常积累,通常在烧伤中见到.
- 它阻碍了伤口愈合,增加了感染风险.
- 目前的治疗方法,如银酸盐是痛苦的,并可能导致痕,导致对替代品的兴趣.
研究的目的:
- 评估一种新的局部治疗方法的疗效和安全性,用于烧伤中高颗粒组织的治疗.
- 为了评估使用50/50的氨和多利斯林混合物的结果.
- 为了确定这个治疗方案的解决时间和成功率.
主要方法:
- 在2017年1月1日至2021年8月30日的第三级烧伤中心进行了回顾性审查.
- 92名患有高分离组织的患者接受了局部50/50的氨和多利斯林混合物治疗.
- 分析了包括解决率,解决时间和替代治疗需求在内的结果.
主要成果:
- 在92名患者中,有88名患者 (95.7%) 通过局部治疗实现了超细粒度溶解.
- 41%的高颗粒区在两周内得到解决.
- 平均解决时间为27.5±2.5天,只有4.3%需要酸银或手术.
结论:
- 一种50/50的氨和聚氨酸混合物是一种有效且安全的治疗方法,用于烧伤中高颗粒组织的治疗.
- 这种新的局部配方为传统的,更具侵入性的治疗方法提供了可行的替代方案.
- 建议进行进一步的前性研究,以确认疗效和安全性.
相关概念视频
01:19Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
120
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
120
01:22Burn Injuries
2.5K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
2.5K