结构和功能大脑网络连接在不同的国王的阶段在患有肌缩侧面硬化症的患者
Edoardo G Spinelli1, Alma Ghirelli1, Silvia Basaia1
1From the Neuroimaging Research Unit (E.G.S., A.G., S.B., E.C., V.C., C.C., M.F., F.A.), Division of Neuroscience, and Neurology Unit (E.G.S., A.G., T.R., P.S., Y.M.F., M.F., F.A.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (E.G.S., A.G., T.R., M.F., F.A.); Neurorehabilitation Unit (N.R., M.F.), and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Neurology
|January 2, 2024
概括
大脑连接MRI显示,在肌缩侧面硬化症 (ALS) 阶段,感觉运动网络的进展性破坏. 这种MRI连接学方法可能有助于阶段ALS进展,并为临床试验分层患者.
科学领域:
- 神经成像是一种神经成像.
- 在Connectomics上,我们提供了连接.
- 神经退行性疾病 神经退行性疾病
背景情况:
- 肌缩侧面硬化症 (ALS) 缺乏验证的生物标志物来确定疾病的阶段.
- 客观标记对于设计ALS临床试验和确保患者队列同质性至关重要.
研究的目的:
- 评估ALS临床阶段的结构和功能性大脑连接变化.
- 探索MRI连接学作为一种工具,用于对ALS的客观疾病分期.
主要方法:
- 观察性研究包括104名ALS患者和61名健康对照 (HC).
- 大脑MRI (3T) 使用扩散张力和静止状态fMRI进行结构和功能连接分析.
- 基于网络的统计 (NBS) 和与临床/认知措施的相关性分析.
主要成果:
- 随着ALS阶段的进展,观察到传感运动网络结构连接的逐渐减少.
- 功能连接显示了阶段依赖的变化,基底/时间回路的增加 (第三阶段) 和前时间回路的减少 (第四阶段).
- 结构连接性与ALS功能评级尺度修订 (ALSFRS-r) 评分和上部运动神经元负担相关.
结论:
- 大脑MRI连接学量化了ALS中渐进的结构连接破坏,反映了疾病的阶段.
- 前功能断开的特征是晚期的ALS.
- 磁力共振成像连接学为确定ALS大脑病理和临床进展提供了一种可重复的方法.
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