身体质量指数与脑内出血患者的功能结果之间的关联
Andrea Becerril-Gaitan1, Dale Ding1, Natasha Ironside1
1From the Departments of Neurosurgery (A.B.-G., C.-J.C.) and Neurology (J.A., S.I.S.), The University of Texas Health Science Center at Houston; Department of Neurosurgery (D.D.), University of Louisville, KY; Department of Neurosurgery (N.I.); Departments of Neurology and Public Health Sciences (A.M.S., B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology and Rehabilitation (F.D.T.), University of Illinois College of Medicine, Chicago; Department of Neurology (M.L.F., D.W.), University of Cincinnati, OH; Department of Neurology (M.S.E.), Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York; Department of Neurology (S.K.) and John P. Hussman Institute for Human Genomics (J.L.M.), University of Miami Miller School of Medicine, FL; Department of Neurology and Neurocritical Care and Stroke (G.S.), Keck School of Medicine, University of Southern California, Los Angeles; Department of Neurology (S.J.K.), University of Maryland School of Medicine, Baltimore; Department of Neurology (D.J.M.), MedStar Georgetown University Hospital, Washington, DC; Department of Neurology (N.G.), University of Colorado School of Medicine, Aurora; Departments of Neurology and Neurosurgery (M.M.), University of Tennessee Health Sciences, Memphis; Department of Neurology (C.E.H.), University of Texas Southwestern, Dallas; Department of Neurology (M.R.F.), Emory University, Grady Memorial Hospital, Atlanta, GA; Departments of Anesthesiology and Neurology (M.L.J.), Duke Clinical Research Institute, Duke University, Durham, NC; and Henry and Allison McCane Center for Brain Health and Center for Genomic Medicine (C.D.A.), Massachusetts General Hospital, Massachusetts, Boston.
较高的体重指数 (BMI) 与脑内出血 (ICH) 患者的更好的生存和功能结果有关. 在ICH患者中,这种肥胖悖论效应在不同种族和民族群体中观察到.
科学领域:
- 神经学 神经学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 这是一个很棒的节目,这是一个很棒的节目.
- 肥胖的悖论 肥胖的悖论
- 在脑内出血 (ICH) 表明肥胖可能是保护性的,但证据是有争议的.
- 调查身体质量指数 (BMI) 和ICH结果之间的关联至关重要.
研究的目的:
- 为了确定BMI和ICH患者的功能结果之间的关联.
- 为了检查种族/种族是否会改变BMI-ICH结果关系.
主要方法:
- 从脑内出血的种族/种族变异研究中分析了2841名患者.
- 包括自发性ICH患者和可用的BMI数据.
- 使用回归模型评估90天死亡率,功能状态 (mRS,巴特尔指数) 和自我报告的健康状况.
主要成果:
- 超重和肥胖患者 (BMI ≥25 kg/m2) 与正常体重患者相比,90天死亡率明显降低.
- 较高的BMI与90天修改的兰金尺度 (mRS),EQ-5D和EQ-5DVAS得分的改善有关.
- 观察到BMI和90天死亡率之间的反向关系 (aOR = 0.97 [0.96-0.99]).
- 在BMI和种族/种族或性别之间没有发现显著的相互作用,但年龄与90天的mRS产生相互作用.
结论:
- 较高的BMI与ICH患者的死亡率降低和功能结果改善有关,支持肥胖悖论.
- 在ICH中较高的BMI的有益影响似乎在种族/族群和性别之间是一致的.
- 年龄可能会显著影响ICH患者的功能结果,这些患者的BMI有所变化.
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