口腔健康和大脑健康:原因,后果或混?
Steven J Kittner1, Breana L Taylor1
1From the Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland.
Neurology
|January 2, 2024
概括
与全身炎症相关的牙周病可能会增加心血管疾病和认知能力下降的风险. 需要进一步的研究来确认因果关系,并解决这些关联中的混因素.
科学领域:
- 口腔健康研究 口腔健康研究
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 关于牙周病与心血管疾病 (CVD),包括中风之间的联系,存在不同的发现.
- 牙周病与全身炎症有关,这是动脉样硬化疾病的已知因素.
- 新出现的证据表明牙周病与认知衰退/痴呆症之间存在联系.
研究的目的:
- 探索牙周病与心血管疾病之间的关联.
- 研究牙周病与认知衰退之间的关系.
- 了解系统性炎症在这些关联中的潜在作用.
主要方法:
- 审查了观察性流行病学研究.
- 考虑了纵向研究设计.
- 分析的重点是关联和潜在的因果作用.
主要成果:
- 一些研究表明血清抗体对牙周病原体与冠状动脉心脏病 (CHD) 相关联.
- 纵向研究支持牙周病与认知衰退之间的关联.
- 系统性炎症可能会调解牙周病和动脉样硬化疾病之间的联系.
结论:
- 牙周病可能在心血管疾病和认知衰退中发挥作用,可能是通过全身炎症.
- 限制包括混变量 (饮食,口腔卫生,宿主反应) 和潜在的反向因果关系.
- 牙周病是一种潜在的可修改条件,突出其公共卫生意义.
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