与神经髓炎光学谱障碍患者认知功能障碍相关的流行,人口和临床因素
Luka Vlahovic1, Jamie McDonald1, Jessica Hinman1
1From the Providence Multiple Sclerosis Center (L.V.), Providence Brain and Spine Institute, Portland, OR; Departments of Neurology and Neurological Sciences (J.M., A.T., C.L., G.D., M.H.H.), and Epidemiology and Population Health (J.H., L.M.N.), Stanford University School of Medicine; Sparta Science (J.H.), Menlo Park, CA; Department of Pediatrics (C.P., L.J.C.), Data Coordinating Center, University of Utah School of Medicine, Salt Lake City; Department of Medicine (M.R.Y.), Geffen School of Medicine, University of California, Los Angeles; Division of Molecular Medicine (M.R.Y.), and The Lundquist Institute for Infection & Immunity, Harbor-UCLA Medical Center (M.R.Y.), Torrance, CA; and Department of Neurology (M.B.), Creighton University School of Medicine, Omaha, NE.
34%的神经炎光学谱系障碍 (NMOSD) 患者经历认知功能障碍 (CD). 连续测试显示,30%的NMOSD患者表现出认知能力下降,强调需要更好的查工具.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 临床神经学 临床神经学
背景情况:
- 神经脊髓炎光学谱系障碍 (NMOSD) 是一种慢性自身免疫性中枢神经系统脱髓化疾病,向水素-4 (AQP4).
- 认知功能障碍 (CD) 是NMOSD患者未被认可的并发症.
- 了解CD的患病率和相关因素对于患者管理至关重要.
研究的目的:
- 为了确定认知功能障碍 (CD) 在多样化的NMOSD患者队列中的患病率.
- 确定与NMOSD中CD相关的临床和人口学变量.
主要方法:
- 一项观察性,回顾性研究,对NMOSD患者进行纵向随访.
- 蒙特利尔连续认知评估 (MoCA) 用于评估随时间推移的认知功能.
- 统计分析包括t测试,ANOVA,千二测试,线性回归和混合效应模型.
主要成果:
- 34%的NMOSD患者 (75/219) 符合CD (MoCA <26) 的标准.
- 较低的神经障碍,减少疼痛和高等教育水平与更好的MoCA分数相关.
- 与白人患者相比,黑人患者的CD更为明显;与复发率,年龄,性别,疾病持续时间,AQP4状态或脑损伤没有发现任何关联.
结论:
- 这项研究代表了迄今为止在多样化的NMOSD队列中对CD的最大调查.
- 很大一部分NMOSD患者患有轻度至中度的CD,显著的百分比显示连续测试下降.
- 这些发现强调了需要加强查工具和在NMOSD管理中全面评估CD的必要性.
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