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血糖变量的关联与血管负担的成像标记物,β-粉样蛋白,大脑缩和认知障碍的成像标记物
Hyemin Jang1, Sungjoo Lee1, Sungsik An1
1From the Alzheimer's Disease Convergence Research Center (H.J., S.A., Y.P., S.-J.K., B.K.C., J.H.K., H.J.K., D.L.N., J.P.K., S.W.S.), Samsung Medical Center; Department of Digital Health (H.J., S.L., K.K., S.W.S.), Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University; Department of Neurology (H.J., H.J.K., J.P.K., S.W.S.), Samsung Medical Center, Sungkyunkwan University School of Medicine; Neuroscience Center (H.J., H.J.K., J.P.K., S.W.S.), Samsung Medical Center; Happymind Clinic (D.L.N.); Biomedical Statistics Center (K.K.), Research Institute for Future Medicine, Samsung Medical Center; and Department of Data Convergence and Future Medicine (K.K.), Sungkyunkwan University School of Medicine, Seoul, Korea. Dr. Jang is currently at the Department of Neurology, Seoul National University Hospital, Korea.
血糖变异性 (GV) 的增加与大脑变化和认知衰退有关,这表明它可能是预防痴呆症的可修改风险因素.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 老年学是指老年学的学科.
背景情况:
- 血糖变化 (GV) 是代谢健康的一个新兴因素.
- 它与神经退行性标记物和认知功能的关联需要进一步调查.
研究的目的:
- 检查GV和神经成像标记物之间的关系,包括白质超强度 (WMH) 和β-粉样蛋白 (Aβ) 沉积.
- 评估GV与大脑缩和认知障碍之间的关联.
主要方法:
- 对688名没有痴呆症的参与者进行了回顾性队列研究.
- 评估GV使用个人内部访问到访问的变异性,快速葡萄糖 (FG) 水平.
- 使用了AβPET,脑MRI,神经心理测试和多变量回归分析.
主要成果:
- 增加的GV预测了严重的WMH和更高的Aβ吸收.
- GV与前额执行和记忆功能障碍相关,部分由WMH和Aβ调解.
- Aβ吸收调解了GV和海马体积和体厚度之间的关系.
结论:
- 增加的GV与血管和阿尔茨海默病风险因素和神经退行性标志物有关.
- 这些因素有助于认知障碍.
- 在预防痴呆症方面,GV可能是一个可修改的目标.
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