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尿路微生物组对博托克斯的反应

Kasey M Palm¹, Megan K Abrams², Sarah B Sears²

¹Division of Female Pelvic Medicine and Reconstructive Surgery, Urology Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA. Kasey.m.roberts@gmail.com.

International urogynecology journal

|January 2, 2024

概括

对于过度活跃的膀进行博托克斯治疗可能会改变尿路微生物群. 尿路微生物组的特定细菌变化可以预测接受肉毒素注射的患者的治疗反应.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
微生物学微生物学
免疫学免疫学免疫学

背景情况:

过度活跃的膀 (OAB) 是一种常见的疾病,影响生活质量.
毒素 (Botox) 注射是对OAB的一种成熟的治疗方法.
尿路微生物组在OAB中的作用及其对治疗的反应尚不清楚.

研究的目的:

调查博托克斯是否会改变OAB患者的尿路微生物组.
为了确定尿路微生物组的变化是否预测了对Botox的治疗反应.

主要方法:

多中心前性队列研究68名OAB患者接受Botox治疗.
在治疗前 (S1) 和治疗后4周 (S2) 采集的尿样.
用于微生物组分析的16S rRNA测序;分析治疗反应的临床数据.

主要成果:

受访者显示,Botox后的Beauveria bassiana,Xerocomus chrysenteron,Crinipellis zonata和Micrococcus luteus的丰富性增加了. 在这些受访者中,Botox后的Beauveria bassiana,Xerocomus chrysenteron,Crinipellis zonata和Micrococcus luteus的丰富性增加了.
没有反应的人在Botox后显示了Pseudomonas fragi的丰度下降.
治疗前的尿路微生物组组成在响应者和不响应者之间,以及在治疗后发生尿路感染的人和没有发生尿路感染的人之间有所不同.

结论:

博托克斯治疗似乎会诱导OAB患者尿路微生物组的纵向变化.
独特的尿路微生物组简介可以区分博托克斯反应者和不反应者.

关键词:

博托克斯 (Botox) 是一种尿道微生物组是什么意思乌罗生物组是人类的生命体.泌尿和妇科泌尿和妇科

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