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在APE1/REF-1和癌症的特征

Priscyanne Barreto Siqueira¹, Mariana Moreno de Sousa Rodrigues², Ísis Salviano Soares de Amorim^3,4

¹Departamento de Biofísica e Biometria, Laboratório de Biologia do Câncer, Universidade do Estado do Rio de Janeiro, Instituto de Biologia Roberto Alcântara Gomes, Rio de Janeiro, Brasil. priscyannebs@gmail.com.

Molecular biology reports

|January 2, 2024

概括

阿普里尼克/阿普里米尼克内核酶-1 (APE1/REF-1) 对于DNA修复至关重要,并调节关键的促进癌症的因素. 准APE1,特别是其氧化还原活性,在各种癌症中显示出治疗潜力.

科学领域:

分子生物学分子生物学
癌症生物学癌症生物学
生物化学生物化学

背景情况:

APE1/REF-1具有DNA修复 (内核酶) 和转录因子调节 (redox) 活动.
APE1的氧化还原域调节了关键的转录因子,如AP-1,NF-κB,HIF-1α和STAT3.
这些转录因子参与了包括生长,炎症和血管生成在内的基本细胞过程.

研究的目的:

审查APE1/REF-1在癌症发展中的作用.
探索APE1在癌症特征中的参与.
突出针对癌症APE1的治疗潜力.

主要方法:

来自PubMed. 的原始文章和评论的文献综述.
专注于研究APE1/REF-1与癌症有关的研究.
分析APE1在DNA修复和氧化还原调节中的双重功能.

主要成果:

APE1/REF-1在各种人类恶性瘤中过度表达,包括肺癌,结肠癌,卵巢癌,前列腺癌和乳腺癌.
内核酶和氧化还原域都对癌细胞至关重要,氧化还原活性特别重要.
APE1的表达和活性与癌症的进展,攻击性,扩散,入侵,炎症,血管生成和抵抗细胞死亡有关.

结论:

APE1/REF-1 在多种癌症发展过程中发挥着基本作用.
APE1/REF-1在癌症特征中的参与表明它是一个有希望的治疗点.
针对APE1/REF-1活动可能为癌症治疗提供一种新的策略.

关键词:

在APE1中,APE1是APE1.癌症癌症癌症癌症癌症的进展情况.标志性的标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标瘤发生的起源

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