一般人群中的肺功能和动脉样硬化:因果关系和临床影响
Gunnar Engström1, Erik Lampa2, Koen Dekkers3
1Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden. Gunnar.Engstrom@med.lu.se.
European journal of epidemiology
|January 2, 2024
概括
降低肺功能和动脉样硬化是相关的,但不是因果关系. 虽然低肺功能可能表明动脉样硬化,但它可能不会独立于其他心血管风险来预测它.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 肺功能下降与心血管死亡率有关.
- 肺功能和动脉样硬化之间的关联仍然不清楚.
- 动脉样硬化是导致心血管疾病的关键因素.
研究的目的:
- 为了研究肺功能和动脉样硬化之间的关系.
- 为了确定肺功能下降是否与动脉样硬化有因果关系.
- 评估肺功能测量在预测动脉样硬化的有用性.
主要方法:
- 基于人口的研究 (瑞典CArdioPulmonary BioImage研究) 对29593名年龄在50-64岁的人进行了研究.
- 测量包括肺功能,肺气,冠状动脉CT血管造影,冠状动脉,动脉斑块和脚-手腕指数.
- 使用双样本孟德尔随机化的结果得到证实.
主要成果:
- 下肺功能和肺气与动脉样硬化增加有关.
- 这些关联在调整心血管风险因素后得到减弱.
- 通过孟德尔的随机化,没有通过孟德尔的随机化确定肺功能和动脉样硬化的因果关系.
结论:
- 肺功能下降和动脉样硬化是相关的,但可能没有因果关系.
- 肺功能评估可能不会为预测亚临床动脉样硬化常规危险因素增加显著价值.
- 偶然发现的低肺功能需要考虑潜在的动脉样硬化.
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