牛乳酸的免疫调节与骨质素一起促进免疫系统的发育和成熟
Chuangang Li1,2, Yao Lu1,2, Jian Wang2
1Key Laboratory of Functional Dairy, Co-Constructed by Ministry of Education and Beijing Municipality, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, China.
一种新的婴儿配方成分Lactoferrin:Osteopontin (LOP) 显示,在婴儿中增强了免疫系统的发展和保护. 这种协同的蛋白质比例为婴儿营养和配方奶粉创新提供了一个有希望的新途径.
科学领域:
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
- 微生物学 微生物学
背景情况:
- 婴儿的免疫系统是不成熟的,需要营养支持的发展.
- 像乳蛋白 (LF) 和骨质蛋白 (OPN) 这样的母乳蛋白具有重要的免疫调节功能.
- 之前的研究表明1:5的LF:OPN比率 (LOP) 对肠道屏障保护具有协同作用.
研究的目的:
- 研究LF:OPN比率 (LOP) 在肠道屏障保护之外的潜在协同免疫调节效应.
- 在婴儿模型中评估LOP对免疫细胞发育和对炎症挑战的反应的影响.
主要方法:
- 在体外模型中使用了脂聚糖 (LPS) 诱导的巨细胞炎症.
- 使用LPS诱导的肠道炎症和生命早期发展的体内模型.
- 分析了免疫细胞分泌物,胸腺和骨髓细胞活性,以及内微生物群组成.
主要成果:
- 与单独的LF或OPN相比,LOP在发育免疫细胞中显著增加了关键的免疫因子 (粒细胞-巨细胞殖民地刺激因子,干细胞因子,白血素-3,胸蛋白,白血素-10).
- LOP证明了对LPS诱导的免疫细胞和细胞因子改变的保护作用.
- 补充LOP改变了内微生物群的组成,增加了诸如Rikenellaceae和Muribaculum之类的有益细菌.
结论:
- 与单个蛋白质相比,LF:OPN比率 (LOP) 具有优越的免疫调节特性,支持免疫发育和弹性.
- LOP显示出作为婴儿营养有效免疫修饰剂的潜力.
- 这些发现为创新婴儿配方奶粉提供了科学基础,这些奶粉具有增强的免疫增强能力.
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