用磁共振成像和三维骨架化测量儿科健康和便秘的结肠长度
Hayfa Sharif1,2,3, Caroline L Hoad2,4, Nichola Abrehart1,2
1Nottingham Digestive Diseases Centre, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
PloS one
|January 2, 2024
概括
功能性便秘的孩子的结肠比健康的孩子要长得多. 来自MRI研究的这一发现可能会导致新的诊断成像方法,以了解结肠功能和病理.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 医疗成像医学成像
- 结肠直肠手术 结肠直肠手术
背景情况:
- 之前的研究表明,健康儿童和功能性便秘 (FC) 儿童之间的结肠体积存在差异.
- 儿童的结肠长度测量一直是有限的,通常依赖于间接或非生理方法.
研究的目的:
- 准确测量患有FC的儿童未受到干扰的结肠的长度,并将其与健康对照进行比较.
- 调查结肠长度与人体/体积参数之间的潜在相关性.
主要方法:
- 磁共振成像 (MRI) 用于对19名健康儿童和16名被诊断为FC的儿童的结肠进行成像.
- 在手动对结肠区域进行细分后,使用了先进的3D骨架化图像分析技术.
- 结肠长度标准化为身体表面积进行比较分析.
主要成果:
- 与健康对照组 (56±2 cm/m2) 相比,患有FC的儿童的结肠总长度显着更长 (69±3 cm/m2).
- 两组之间在上升的结肠和西格直肠长度上发现了显著的差异.
- 结肠总长度与年龄,身高,体重和结肠体积有正相关性.
结论:
- 这项研究表明,有功能性便秘和没有功能性便秘的儿童之间结肠长度存在显著差异.
- 通过MRI测量结肠长度,为儿科功能性肠道疾病提供了潜在的客观诊断成像终点.
- 这些发现有助于更好地了解结肠形态及其在功能病理学中的作用.
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