阿尔法-1抗素缺乏和妊娠并发症和分娩结果:丹麦的一项基于人口的队列研究
Helen T Orimoloye1, Di He2, Tong Li2
1Department of Rehabilitation and Health Services, University of North Texas, Denton, Texas, United States of America.
PloS one
|January 2, 2024
概括
阿尔法-1抗素缺乏症 (AATD) 会增加母亲和新生儿的风险,包括低出生体重和孕前. 怀孕期间的密切监测对于患有AATD的母亲来说至关重要,以改善分娩结果.
科学领域:
- 产周医学 产周医学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 阿尔法-1抗素缺乏症 (AATD) 与肺部和肝脏疾病有关.
- 没有任何大规模的研究检查过AATD与出生结果的关联.
研究的目的:
- 调查AATD的母亲和儿童怀孕并发症和不良分娩结果的风险.
主要方法:
- 从1973年到2013年,分析了一大批丹麦的母亲和孩子 (n=2,027,229).
- 普森回归被用来检查AATD与出生结果/怀孕并发症之间的关联.
主要成果:
- AATD与期内低出生体重 (RR=2.04),剖腹产 (RR=1.59),早产 (RR=1.54) 和孕前 (RR=2.64) 相关.
- 在非吸烟母亲的孩子中,AATD还与腹周的最低四分位数有关 (RR=1.55).
结论:
- 患有AATD的母亲需要密切监测怀孕,以减轻出生不良结果的风险.
- 在怀孕期间进行常规的α-1抗素查可能对有肺部和肝脏疾病史的母亲有益.
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